Cut chicken breast into bite-sized pieces and season with salt, pepper, garlic powder, and onion powder.
Heat olive oil in a large skillet over medium heat. Add seasoned chicken and sauté for 5-7 minutes until golden brown.
Drizzle honey and add sliced bell peppers to the skillet. Cook for an additional 3-4 minutes.
Boil salted water in a pot, add macaroni, and cook until al dente. Drain and set aside.
Melt butter in a saucepan, whisk in flour to create a roux, gradually add milk, and stir in cheddar cheese until melted.
Mix cooked macaroni with cheese sauce and fold in honey pepper chicken and bell peppers.
Preheat oven to 350°F (175°C), transfer mixture to a greased baking dish, sprinkle breadcrumbs, and bake for 20-25 minutes.
Let cool for a few minutes, serve warm, and garnish with fresh herbs if desired.